Best Pain Relievers
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CVS Health Extra Strength Acetaminophen Pain Reliever & Fever Reducer 500 MG Liquid, Cherry, 8 FL OZ
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Find reviews of customer favorites
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Tylenol Extra Strength Acetaminophen Dissolve Packs, Berry
Tylenol
I love that it was simple and easy to take AND the taste is great.
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FeverAll Acetaminophen Suppositories Pain Reliever/Fever Reducer, 6 CT
Feverall
We always give our baby this medicine when she gets fevers, works great and works fast... Works faster than any other medicine. Love it. I...
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Motrin IB Ibuprofen 200 MG Tablets
Motrin
The people are very professional and they always help me out keep up the good work thanks
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CVS Health Back & Muscle Pain Naproxen Sodium 220 MG Tablets
CVS Health
Amazed at how well it works! And the price was good.
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CVS Health Extra Strength Acetaminophen Pain Relief 500 MG Caplets, 1000 CT
CVS Health
Had coupons. Needed Tumeric & acetaminophen. Ordered what I needed. Asked for it to be shipped. Received my shipment in a very timely mann...
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Best OTC Pain Relief
When everyday aches or unexpected pains flare up, choosing the best OTC pain relief from CVS can help you bounce back and enjoy a better day. Our trusted options provide relief for everything, from headaches and arthritis to muscle soreness and back pain. Choose fast-acting tablets for on-the-go pain relief or long-lasting topical gels that reduce discomfort. With multiple formulas to meet different needs and sensitivities, finding the best pain medicine starts with outlining your symptoms, identifying causes and knowing what works best for your body.
Which Over-the-Counter Pain Medication Should I Use?
Choose the best OTC pain relief by first considering the type and cause of your discomfort. For headaches, fever and mild inflammation, acetaminophen may work well and doesn't usually irritate your stomach. But be careful — too much of this drug can damage your liver.
Muscle aches, arthritis or swelling may respond better to nonsteroidal anti-inflammatory drugs, such as ibuprofen or naproxen. These options help offer longer-lasting results by reducing inflammation at its source, yet they're generally harder on your stomach. Topical options, including lidocaine patches or menthol-based creams, can deliver localized pain relief without affecting your liver or stomach, making them an excellent choice for muscle soreness and injuries such as sprains.
Factors to Consider When Choosing Pain Medicine
Factor in your age, health conditions and other medications when selecting the best pain medicine from CVS. If you have a liver condition or consume alcohol regularly, avoid acetaminophen to help prevent further organ damage. Check with your doctor before using NSAIDs if you have a history of heart problems, high blood pressure or ulcers. These drugs promote blood clotting and water retention yet can erode the stomach lining, leading to heartburn or nausea.
Allergies and drug interactions also matter, especially if you're managing chronic health conditions. When in doubt, speak with a CVS pharmacist or visit our Minute Clinic for more personalized guidance.
Top-Rated OTC Pain Relief Products
CVS carries a range of high-quality brands, offering our customers some of the best over-the-counter pain medication options available. Our top pain relievers include:
Advil for inflammation and joint or muscle pain
Tylenol for fever, headache and general pain
Icy Hot for topical relief of localized pain
ThermaCare for drug-free heat therapy relief
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Extra Strength Pain Relief Reviews , Tylenol Extra Strength Reviews, Tylenol Rapid Release Gels Reviews